The prefix of a legendary-type weapon dropped by Legendary Enemies determine its bonus effects. See the list below for the prefix's effects.


| Automatic | Automatic fire mode. (Laser Musket only) |
| Berserker's | Does more damage the lower the player character's Armor Resistance. (Up to 200% at 0 resistance) |
| Bloodied | Does more damage the lower the health is. |
| Cavalier's | Reduces damage by 15% while blocking or sprinting. |
| Crippling | 50% more limb damage. |
| Enraging | Critical hits cause target to frenzy. |
| Explosive | Bullets explode on impact doing 15 points area-of-effect damage. |
| Exterminator's | Does 50% more damage against Mirelurks and bugs. |
| Freezing | Does 10 points cryo damage and will freeze targets on critical hits. |
| Furious | Increased damage after each consecutive hit on the same target. |
| Ghoul slayer's | Does 50% more damage against ghouls. |
| Hunter's | Does 50% more damage against animals. |
| Incendiary | Sets target on fire for 15 points of damage. |
| Instigating | Does double damage if the target is at full health. |
| Irradiated | Does 50 points additional radiation damage. |
| Junkie's | Does increased amounts of damage the more withdrawal effects the Sole Survivor is suffering. |
| Kneecapper | 20% chance to cripple the target's leg. |
| Lucky Weapon | Critical shots do double damage and the critical meter fills 15% faster. |
| Medic's | Heals target instead of hurting them. |
| Mighty | Deals an additional 25% damage. |
| Mutant slayer's | Does 50% more damage against Super Mutants. |
| Never Ending | Sets ammo capacity equal to the amount one is carrying. |
| Nimble | Provides 75% faster movement while aiming. |
| Nocturnal | Does increasing amounts of damage as the night grows longer and less damage during the day. |
| Penetrating | Ignores 30% of the target's damage and energy resistance. |
| Plasma infused | Adds 10 points of energy damage and can turn enemies into goo. |
| Poisoner's | Target is poisoned for 10 seconds. |
| Powerful | Provides 25% more damage. |
| Quickdraw | Costs 25% fewer Action Points. |
| Rapid | 25% faster fire rate, 15% faster reload. |
| Relentless | Refills Action Points on a critical hit. |
| Sentinel's | Take 15% less damage while standing and not moving. |
| Staggering | Chance to stagger on hit. |
| Stalker's | If not yet in Combat, increases V.A.T.S. accuracy but costs more AP. |
| Troubleshooter's | Does 50% more damage against robots. |
| Two shot | Fires an additional projectile. Decrease in accuracy. |
| VATS enhanced | Improved V.A.T.S. hit chance, 25% less Action Point cost. |
| VATS enhanced | 40% less Action Point cost. |
| Violent | Deals +25% damage and limb damage, but has more recoil. |
| Wounding | Targets bleed for 25 points of additional damage. |
Source: Fallout Wikia