Walkthrough
After obtaining the Tea from the elderly woman in the Celadon City Mansion and defeating Team Rocket in both the Rocket Hideout and Pokemon Tower, you will finally be able to go into Saffron City. Unfortunately, upon your arrival you will learn that Team Rocket has taken over the city and is currently occupying the Silph Co. Building within Saffron City. It will be up to you to stop them once again before being able to unlock the Saffron City Gym.
Much like the Rocket Hideout, the Silph Co. Building is a giant maze, one that uses portal pads to ascend and descend the floors of the building. Each portal pad will lead you to a different location on a certain floor, basically forcing you to try out every single portal pad and battle every Team Rocket Member that stands before you and Giovanni if you don't know the easy way around it.
If looking to cruise through the Silph Co. Building, however, head to the 5th Floor and find the Card Key. With it, you can open every door to the building and can avoid the portal pad maze. From there, go to the 3rd Floor and open the room to the left of the center. Use the portal pad on the far left of this room, and then use the next portal pad it takes you to. By doing so, you will come to certain room on the 7th Floor. Within this room is another portal pad, one that will lead you directly to the President's Room where Giovanni can be found. Defeat Giovanni to have Team Rocket be removed from Saffron City and earn the Master Ball.
Thunder Wave: Move Tutor Can Be Found On The 2nd Floor
Lapras: Can Be Obtained From A Person On The 7th Floor
Pokemon Trainers
2nd Floor:
Team Rocket Grunt: Level 25 Golbat, Level 25 Zubat, Level 25 Zubat, Level 25 Raticate, Level 25 Zubat
Team Rocket Grunt: Level 29 Cubone, Level 29 Zubat
Scientist Jerry: Level 28 Magnemite, Level 28 Voltorb, Level 28 Magneton
3rd Floor:
Team Rocket Grunt: Level 28 Raticate, Level 28 Hypno, Level 28 Raticate
Scientist Jose: Level 29 Electrode, Level 29 Weezing
4th Floor:
Team Rocket Grunt: Level 28 Ekans, Level 28 Zubat, Level 28 Cubone
Team Rocket Grunt: Level 29 Machop, Level 29 Drowzee
Scientist Rodney: Level 33 Electrode
5th Floor:
Scientist Beau: Level 26 Magneton, Level 26 Koffing, Level 26 Weezing, Level 26 Magnemite
Team Rocket Grunt: Level 33 Arbok
Team Rocket GruntL Level 33 Hypno
Juggler Dalton: Level 29 Kadabra, Level 29 Mr. Mime
6th Floor:
Team Rocket Grunt: Level 29 Machop, Level 29 Machoke
Team Rocket Grunt: Level 28 Zubat, Level 28 Zubat, Level 28 Golbat
Scientist Taylor: Level 25 Voltorb, Level 25 Koffing, Level 25 Magneton, Level 25 Magnemite, Level 25 Koffing
7th Floor:
Team Rocket Grunt: Level 29 Cubone, Level 29 Cubone
Team Rocket Grunt: Level 29 Sandshrew, Level 29 Sandshrew
Team Rocket Grunt: Level 26 Raticate, Level 26 Zubat, Level 26 Golbat, Level 26 Rattata
Scientist Joshua: Level 29 Electrode, Level 29 Muk
8th Floor:
Team Rocket Grunt: Level 26 Raticate, Level 26 Arbok, Level 26 Koffing, Level 26 Golbat
Team Rocket Grunt: Level 28 Weezing, Level 28 Golbat, Level 28 Koffing
Scientist Parker: Level 29 Grimer, Level 29 Electrode
9th Floor:
Team Rocket Grunt: Level 28 Golbat, Level 28 Drowzee, Level 28 Hypno
Team Rocket Grunt: Level 28 Drowzee, Level 28 Grimer, Level 28 Machop
Scientist Ed: Level 28 Voltorb, Level 28 Koffing, Level 28 Magneton
10th Floor:
Scientist Travis: Level 29 Magnemite, Level 29 Koffing
Team Rocket Grunt: Level 33 Machoke
11th Floor:
Team Rocket Grunt: Level 25 Rattata, Level 25 Rattata, Level 25 Zubat, Level 25 Rattata, Level 25 Ekans
Team Rocket Grunt: Level 32 Exeggcute, Level 32 Drowzee, Level 32 Marowak
Boss Giovanni: Level 37 Nidorino, Level 35 Kangaskhan, Level 37 Rhyhorn, Level 41 Nidoqueen
Items
2nd Floor:
Ultra Ball: ItemFinder
3rd Floor:
Hyper Potion: On Ground
Protein: ItemFinder
4th Floor:
TM41: On Ground
Full Heal: On Ground
Max Revive: On Ground
Escape Rope: On Ground
Iron: ItemFinder
5th Floor:
Card Key: On Ground
Protein: On Ground
TM01: On Ground
PP Up: ItemFinder
Elixir: ItemFinder
6th Floor:
HP Up: On Ground
X Special: On Ground
Carbos: ItemFinder
7th Floor:
TM08: On Ground
Calcium: On Ground
Zinc: ItemFinder
8th Floor:
Iron: On Ground
Nugget: ItemFinder
9th Floor:
Max Potion: ItemFinder
Calcium: ItemFinder
10th Floor:
Ultra Ball: On Ground
Carbos: On Ground
Rare Candy: On Ground
HP Up: ItemFinder
11th Floor:
Zinc: On Ground
Revive: ItemFinder
Master Ball: Defeat Giovanni