The difficulty of this area will lessened if you kill the two enforcers first. If you did, you’ll only have to deal with sentries and a whole lot less number of guards. You can simply bring a sniper rifle, sneak in the crane’s walkway itself (which serves as the sniper nest in this location) then snipe off the guards. Prioritize the sentries as always and stay in cover as you identify the targets.
After clearing the area, make sure to look around since there’s a bountiful amount of cash here, especially in the main building. The main building’s third floor also has a Vargas painting that you can pick up. Once you're done looting the place, plant the explosives on the fuel tank at the base of the crane and leave the area to trigger the explosion in a cutscene.