As like many of other Fighting Genre Video Games presently on the market, Metroid: Samus Returns has a number of Level of Difficulties that players can choose from. Players begin the game with only the Normal Difficulty; however, they can unlock two further Difficulty Levels as they progress throughout the game. The second toughest mode is Hard Difficulty, which causes opponents to do twice the amount of damage as in Normal Difficulty. The third and final mode is Fusion Difficulty, which allows Samus to use her Fusion Suit but causes opponents to hit four times as hard than in Normal Difficulty.
A player can select the Level of Difficulty when starting a New Saved Game File.