Your Account
    Log into your account here:
       Forgot Password

    Not registered? Sign Up for free
    Registration allows you to keep track of all your content and comments, save bookmarks, and post in all our forums.

5-3: Uroboros Research Facility

Resident Evil 5 Walkthrough and Guide

by Absolute Steve  

Print page (no screenshots)   |   Print page

Resident Evil 5 Guide - Walkthrough

Chapter 5-3: Uroboros Research Facility

| ______|¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯|
|| ____/|       [C5-3] Chapter 5-3: Uroboros Research Facility                 |
|| |__  |______________________________________________________________________|
||___ \ |¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯|
| ___) ||It seems that Chris' arch-enemy is still alive.  It looks like there  |
||____/ |is no other way but to take him on and defeat him.  But how..?        |
|ITEMS  |[] Shotgun Shells, [] Machine Gun Ammo, [] Sapphire (Marquise),       |
|       |[] Machine Gun Ammo, [] Crate x3, [] Box, [] Box x2, Box x5, [] Box x4|
|       |[] Crate, [] Rifle Ammo, [] Hand Grenade, [] Red Herb, [] H&K PSG-1,  |
|       |[] Green Herb, [] Royal Necklace, [] Box x6, [] Box x2, [] Rifle Ammo,|
|       |[] Box, [] Green Herb, [] Box, [] Magnum Ammo, [] First Aid Spray,    |
|       |[] Chalice (Gold), [] Topaz (Brilliant), [] Green Herb x2, [] Vases xx|
|EMBLEMS|3x.                                                                   |
|ENEMIES|1. Majini (Base).                                                     |
|       |2. Licker Beta.                                                       |
|       |3. Reaper.                                                            |
|       |4. Big man Majini.                                                    |
|       |5. ????  ?????? [BOSS].                                               |
|       |                                                                      |

Exit the area to the north and look behind the large fan to the right to spot an elusive [BSAA EMBLEM] behind it.

BSAA Emblem

The room to the west contains [SHOTGUN SHELLS], [MACHINE GUN AMMO] and a [SAPPHIRE MARQUISE]  in the safe. Head down the corridor and grab more [MACHINE GUN AMMO] that's lying on top of a generator near the exit.  In the next room, loot the three [WOODEN CRATES] and a [BOX], then proceed to the research facility hall.

Reapers and Majini’s with machine guns, just watch this video and reach the other side of this enormous hall.

Check the right side of the catwalk to spot two [BOXES], and continue to the east.  Five more [BOXES] can be found in a generator room to your left, and it will be around this time that several Majini's make their appearance.  Kill the ones coming over to you and take cover behind the metal plating on the railing of the catwalk.  Kill the two Majini's on the other side of the catwalk and continue.

Proceed just a little further and you'll encounter a reaper.  Target its weak spots to kill it faster, then take cover behind the metal plate up ahead.  Be SURE to kill any Majini's with stun rods coming your direction; there should be two coming in total.  When you've killed the other Majini's in the distance, continue over the catwalk and enter small room with a powering maching to the east.  Use it to restore power to a lever we'll get to shortly, and loot the four [BOXES], [WOODEN CRATE], and grab the [RIFLE AMMO], [HAND GRENADE], [RED HERB], and the [H&K PSG-1] rifle from the suitcase.

Return to the lever on the south and two Majini's, joined by a Big man Majini are coming over from the platform lift.  Kill the two regular ones first, as they can throw dynamite.  After dealing with them, have one person stand on the platform and have the other use the lever.  If you're playing alone, I suggest you go by yourself.  A few Majini will attack you, two of them have metal shields which don't make things easier, and on top of things they also transform into Cephalo.  There's an other Majini on the east side.

Flip the lever, dodge the Majini and try to kill them asap.

When you're both on the other side, get moving and things start to get rough.  Two Majini's in the distance as armed with rocket launchers, and you don't want to get hit by those!  Other Majini's with stun rods and machine guns will also storm you rather sooner than later, so you're in a tight spot.  Take cover and try to kill the two Majini's with the rocket launchers ASAP with a rifle.  Rush over to that building, killing all Majini's (including several Cephalo) in your way, and deal with another bunch in the control room.  When they're dead, grab the [GREEN HERB] and [ROYAL NECKLACE] here and continue to the next area.

Smash the six [BOXES] here and two more in the circular chamber.  Go down and turn to the green monitor under the stairs to start the elevator.  Several Majini's will stop the elevator by holding down a lever.  If you kill this Majini (use a rifle to zoom in on him), the elevator will start moving again, but it might be tricky to get a steady aim.  Try the following trick:  When you know they're going to come in sight soon, aim slightly left of where they will appear and slightly move your scope to the left as well.  This will result in your scope moving slowly to the right due to the elevator's movement, allowing you to adjust your aim more precisely.

It is also worth mentioning that you can shoot another [BSAA EMBLEM] on the first balcony floor, when the rotating elevator stops for the first time.  Use the above trick to shoot it.

BSAA Emblem

When you've taken care of the Majini's, more will assault you from the upper catwalk.  Quickly kill them as you don't have all that much place for cover, and exit the area by following the catwalk that leads to a door. 

In this area, loot the two [BOXES] to your right and to your left.  Run around the elevator shaft to find [RIFLE AMMO x5], and aim down at the elevator shaft from this spot to shoot a [BSAA EMBLEM].  There's another [BOX] next to the raised bridge, and the power generator is closeby to your right from here.  Call the lift and head up yourself (I can't recommend the AI).

BSAA Emblem

Two lickers appear.  You can handle them, right?  Keep them at a distance with your grenade launcher or any other long range weapon, and continue your way on the corridor.  Whoops, looks like you have some more company!  Again, do your best to keep these suckers away from you.  As you're likely to run out of explosive rounds, resort to your handgun and empty it from a distance.  There's a [BOX] up ahead that usually contains Acid Rounds, so load them in your grenade launcher.  Another box can be found in the distance, but you'll want to quickly run past it as a licker or 10 start chasing you.  Push the container when you get to it and use the Acid Rounds to keep the lickers at a distance.  If you run out, resort to whatever you have left, such as a shotgun. 

With those out of the way, drop down on the cabin and look for a useful [GREEN HERB] and a [BOX].  Jump down in the cabin and unlock the door.  The lockers contain [MAGNUM AMMO], a [FIRST AID SPRAY] and a [CHALICE (GOLD)].  Pull the lever to lower the bridge, and exit the area.  The shiny gem above the exit is a [TOPAZ (BRILLIANT)].  After a few scenes, it's boss time!


This video shows you how to deal with two very powerful foes.

You can get through this fight without firing a single shot, and perhaps that is the best way to go indeed.  You don't want to hurt Jill, and Wesker is basically invincible and you can't kill him.  The goal here is to hold out for seven minutes, like Wesker explicitly mentions at the start of the fight.  You may want to take note of the two [GREEN HERBS] behind each of the stairs so that whenever you need them, at least you know where they are.

Note: If you damage Wesker enough, it is possible to make him retreat.  You'll find a [HEART OF AFRICA] treasure between the stairs as reward.

Run around and stay away from both Wesker and Jill.  Avoid getting hit by their gunfire (hide behind the pillars, for example), and after a short while Wesker kicks Chris through a door.  This allows you to hide from Wesker, making things much easier while hiding.  There are about 15 [VASES] around here (if you have specifics on the treasure here, feel free to submit it - otherwise I'll look into it later), so there's plenty to loot.  When the seven minutes are over, a scene will play and the next phase of the battle begins.


In order to save someone special, you’ll want to rely on other tactics besides shooting. This video shows exactly what you should do.

You need to remove the red device from Jill's chest.  Get near Jill and press the prompted button to talk to her.  Don't get too close or she'll kick you in the nuts, though.  Have one of you (or Sheva's AI) hold her down when Jill is confused by the talk and tap - as FAST as you can - the prompted button to remove the device.

Jill has a few close quarters attacks, but she also uses a machine gun every now and then.  If she does, hide behind the pillars to avoid the gunfire.  Depending on how fast you tap, it will take several attempts to remove the device.  For an indication, it took me 7 times on veteran.

Many people tap with their fingers, and while it does work every now and then, there is a method that allows you to tap buttons much, MUCH faster.  I learnt that from Konami's International Track & Field for the PSOne, in case you were wondering. :p

Tapping with your wrist:
Instead of tapping with your finger, tap with your wrist.  How does that work?  Well, you obviously don't literally tap with your wrist, but you hold your thumb still on the button you want to tap, and you shake/vibrate your controller so your thumb touches the button.  Try and perfect this method, and hold the controller however you like.  I personally place it against my body with one side, it helps me tap faster.

With the device removed, more scenes play and the chapter will be over.

Need some help with this game? Or can you help others?
Click below to go to our questions page to see all the questions already asked and ask your own.
PS 3 | Xbox 360

Comments for 5-3: Uroboros Research Facility

4 comments, latest first.
Aug 31st 2013 Guest
you are aweasome....
ID #307585
Aug 15th 2011 Guest
[video][/video] jill
ID #67430
Jul 25th 2011 Guest
i find fighting wesker both fun and annoying
ID #61209
Nov 13th 2010 Guest
[spoiler][/spoiler] EVERYONE DIES IN 2012
ID #18139