DESCRIPTION: The Lost can be considered the challenge character for Rebirth. Along with having a very strict set of rules for unlocking the character, the Lost does not have any health. That means any hit you take as the lost will end your run. The Dead Cat will be your best bet in giving you multiple opportunities at completing a run as the Lost. The Lost starts with the ability to fly. Most importantly, he can take Devil Deals for free. Seeing as you won’t be able to take damage anyways, your chances of getting a Devil Deal/Angel Room are very high.
UNLOCK: You unlock The Lost by meeting certain specific requirements.
1. Isaac must die to a Mulliboom in The Basement or The Cellar.
2. Magdalene must die to one of her own dropped bombs in The Caves or The Catacombs.
3. Judas must die to a Mom attack in The Depths or Necropolis.
4. Azazel must die to a Satan attack in Sheol.
You can use seeds to make accomplishing these steps a little easier. You can not use a seed for the last step, for Azazel. If you have any item that allows you to have extra lives, like the Dead Cat or 1-Up, you must be on your last life for it to work. Any item that revives you as a different character will not work. In step three if you die to an enemy spawned in the Mom fight, it will not count. Same goes for the Satan fight. You can not die to the Fallen during the fight or it will not count. You are allowed to quit and restart during this process if you feel you do not have a strong enough build to reach the point for the completion of the step.