Challenge: #4 Darkness Falls
Description: The Darkness Falls Challenge requires you to play as Eve and run to Sheol to defeat Satan.
Unlock: You unlock this Challenge by unlocking both Eve and It Lives. You unlock Eve by not picking up any health drops for two consecutive floors and you unlock It Lives by defeating Mom’s Heart 11 times.
Starting Items:
Dark Matter
Dead Bird
Pentagram
Whore of Babylon
Razor Blade
Sacrificial Dagger
Strategy: You start with some great items for this run. The biggest decision you will have is the risk vs. reward in regards to activating your Babylon item. It is more useful since it activates at one red heart for Eve instead of the half for the rest of the cast. You will be starting with the Pentagram which is a Damage Up, so you have some time to try and collect Soul or Dark hearts to protect yourself when you decide to go down to one red heart. You have to make sure if you do decide to activate Babylon, that you avoid red heart pick-ups and Health Up Items. If you have a blood donation machine on the floor, it is okay because you will always be able to get yourself back down to one red heart. Otherwise you will lose Babylon. The razor blade will grant you a damage up, but it is only for that room and it does cause damage in order to receive the boost. Your greatest asset will be the Sacrificial Dagger. It’s very wide protective hitbox will make using it against enemies much easier than other orbitals. You will also find yourself having a much higher chance for Devil Deals for this run. You can take a deal to remove all of your red health, making Babylon a permanent status change.
Completion: Completion of this challenge unlocks the Rune of Dagaz.