Grand Theft Auto: San Andreas - Big Smoke's Missions
You can start taking missions from Big Smoke after completing the “Nines and AK's” mission in Sweet's mission line. The starting point of each of these missions is denoted by with a ‘BS' on the radar.
Big Smoke's House
Mission 1: OG Loc
A member of the gang, Jeffery, has been locked up in prison; he's on parole now, so it's time to pick him up. Follow the yellow icon on the radar to reach the prison and drive into the red marker. After the cutscene, drive to Freddy's house, marked on the radar by the yellow icon, hit the red marker, then get out of the car and ring the doorbell. Jeffery's first deed out of prison? Killing this Freddy. Jeffery's target slips out the back door, hops onto a motorcycle and takes off. What ensues is a potentially lengthy motorcycle chase through the streets of Los Santos.
Jeffery is armed with a Micro SMG, and if you have one of your own, you can also fire at Freddy while on the motorcycle. This doesn't seem to do much good, though, as it is quite hard to actually hit Freddy as he speeds by. It would be best to simply concentrate on following Freddy, because eventually he will park his motorcycle next to a group of gang members and step off, allowing Jeffery and yourself to gun him down. You could probably end this one quickly in the streets, but simply keeping up with the target is work enough, let alone getting close enough to take him out. If you're content with seeing the chase through to the end, just follow Freddy's path exactly. Otherwise you can try to cut him off as he emerges from an alleyway.
Afterwards, head towards the yellow icon on the radar and drive into the red marker in the Burger Shot parking lot to complete the mission.
Mission 2: Running Dog
You're going with Big Smoke to pick up his “cousin.” Get in the car and start towards the yellow icon on the radar; you'd better pick up a weapon from Emmet's while you're at it. When you reach the meeting place, drive into the red marker to trigger a cutscene. All you have to do here is catch up with the dealer and kill him. This is enough, as your target does not run exceptionally fast. While CJ can't sprint forever, the distance between you and your target can be closed quickly by simply tapping the Sprint button. When you're close enough to the target, gun him down to complete the mission.
Mission 3: Wrong Side of the Tracks
Follow the yellow icon on the radar to reach Unity Station. Drive into the red marker there to trigger a cutscene. The four Vagos at the station drop down onto the moving train in an attempt to escape; immediately hop onto the nearby motorbike and speed after the train. All you have to do here is keep up with the train while Smoke fires at the Vagos, all four of which must be dead before the train leaves Los Santos. This mission can be somewhat difficult because each of the four Vagos has quite a bit of health. Not only that, but several obstacles are encountered on the tracks.
Smoke will target the second Vagos (from the back to the front of the carriage) initially, then the first, then third, and finally the fourth. Even if you're riding in front of the train, Smoke still focuses on the targets in that order, so you'll want to trail a bit behind his current target to give him the best shot. Hold down the Accelerate button and move along the tracks until you are a bit ahead of Smoke's current target, then release the Accelerate button, periodically pressing down on it to maintain speed. If the train starts to get too far ahead, hold down the Accelerate button to pick up speed. Make sure you're moving along the outside of the track for best results.
As mentioned, there are a couple of obstacles along the way: an idle car on the tracks that promptly explodes upon impact with the train, and an oncoming train that forces you to take a high ground trail. These obstacles are easily avoided if you can see them coming; slow down when you spot the parked car on the tracks, and listen for Smoke's cue to take to the high ground. The mission's a failure if even one gang member is left standing when the train reaches the city exit.
Mission 4: Just Business
Make your way to the yellow icon on the radar to reach Downtown and drive into the red marker there to get started. Yet again you've managed to find trouble; after the cutscene, you're immediately thrust into the middle of a heated shootout. Remain crouched and take out the hostiles while safely behind cover. When the enemies in the plaza have been dealt with, follow Smoke outside. You'll find yourself in a similar mess once outside; a large number of hostiles are scattered along your escape route. Gun them down and follow Smoke to a nearby motorbike.
What follows is a rather lengthy on-rails sequence; while Smoke drives the motorbike, your task is to keep the pursuing enemies at bay. You're followed by a variety of vehicles, including a large transport truck. Although you have infinite ammo during this portion, don't waste any time firing at the truck, as gunfire is ineffective. Focus on the motorcycles first and foremost because each one holds two gunmen and they are quick and versatile enough to keep up with your bike. Always aim for the driver rather than the gunner, as taking him out will send the motorcycle out of control. Fire at the front of the bike and chances are you'll take out the gunner. The enemy's cars can be trouble too, but if you hit a car grille with enough gunfire, it will eventually catch fire and subsequently explode.
Reach end of the line with both the bike and yourself intact to complete the mission.