"Help Karen hit the vault in one of vegas's high-security casinos"
Karen wants your help causing some mayhem by breaking into the vault of one of frank's casinos (called the City of Saints Casino, named after the last gangstar game). Luckily Karen has a plan, involving lifting the vault key, which is in a location she knows about from one of her contacts. First, we need to get to the Casino, so drive there at your leisure.
Once inside, Karen states that the key is on the other side of the lobby, so you need to fight your way across it. There are lots of police around and more will arrive once you start firing. The key is with the Casino manager, who you will find in a room at the back of the lobby. Fight your way to him and get the key.
Once you have it, you need to make your way back across the lobby and into the vault area. There will be a couple of police inside, after which you can enter the vault itself. As soon as you enter, you are given 3 Wanted Shields. You must wait for Karen to access the computer inside, then police will join you in there. Take cover and deal with them.
There are probably close to ten of these enemies that enter the room. Once you take them out you are free to leave the vault, cross the empty lobby and exit the Casino. Outside, you will be greeted by a large number of police. Dive into your car and drive out of there, but beware, your car will be damaged as the police are shooting to kill by this stage.
you need to lose them, then drop Karen off. They shouldn't be too hard to evade with the circuitous roads around the Casino. Once you've lost them, this tough mission is complete.
Reward: G65,000, Respect: 315,000