"Protect Karen while she blows off some steam"
After all the stress of the previous few chapters, Karen is not too pleased with you. She drives off to fight frank's henchmen but we obviously don't want her to get hurt, so you need to hop on the motorbike across the street or the car parked nearby and chase after her. Make sure she doesn't get over 150m away, or a 15 second timer will start and you will need to catch up with her before it reaches zero.
Soon she reaches her target, and you need to make sure she doesn't take too much damage from the henchmen. Take them all out, and more will arrive in a pair of SUVs. Having dealt with them, Karen agrees to make a swift getaway. You need to fire from the vehicle to make sure the henchmen do not deal too much damage to Karen, and that your vehicle is not destroyed.
There are lots of vehicles you have to deal with, which will also resort to ramming you to get their way. Be sure to use a repair kit on the vehicle if it begins to become too damaged. It can be hard to choose a target as the game is a bit frustrating with its auto-selection, but if you persist with it for long enough and use repair kits, you should be fine.
Once you have fought off all of the henchmen, Karen will park up and the mission will end.
Reward: G400,000, Respect: 1,540,000