"Attack frank in his own home and lead the police to his doorstep"
Karen wants to set frank up - smashing up his villa and making it look like he's lost it and taken out his anger on those closest to him. the press will then be tipped off (the press being the only part of vegas that Frank doesn't have control over), which will force the police to get involved.
Head to frank's Villa to put the plan into motion. Once you get there you are instructed to steal a Heavy Weapon. You can find one on the upper floor of Frank's boathouse, which you can access via the stairs below. You will then have a huge machine gun and four or five guards to contend with.
Move out of the boat house to get close enough to deal some major damage to them. With the first wave taken out, of course more turn up. After a few more waves, which you will be able to take out easily enough with your massive machine gun, you need to head to the marked locations to sabotage frank's Villa.
one of them just involves setting fire to his gazebo. Another has you having to take out frank's Luxury Cars, which are guarded by a few more henchmen. the final once requires you to destroy Frank's boat in the now suspiciously full boathouse. Again there area a few henchmen guarding it. With those three objective taken care of, Jason calls the press who get the police to go the Villa. We need to escape before they can find out it was us.
get in a vehicle and flee the police to cross this mission off. Concentrate on getting out of the Villa complex - use your map to find the side where the police have not gone to - and you shouldn't have too many problems.
Reward: G500,000, Respect: 1,745,000