All the achievements added up equal to 1100 points, more than most games which have 1000 possible points.

Go to each of the Gatherer's Garden vending machines throughout the game. Purchase the Plasmid and Tonic upgrades. Make sure you have enough ADAM to buy the upgrades when you are at the right part of the game.

Load up on all Anti-Personal ammo and Heat-Seeking RPG's and make sure they're loaded. Keep Enrage and Incinerate 3 on hand. So when you start the fight (hit him with needle) and take out your RPG's. Hit him (takes 2 or 3) and he will go back for health. Hit him with the needle again, and be ready to use Incinerate. Once you have take aim with your RPG's (seeing as he's ice you do lots of damage with Incinerate plus it makes the following part easier for the rocket). During this phase he has Bots after you, so do what you want with them. Next and final phase he gains electricity (more like plasma) and Splicers attack. Use Enrage on the Splicers and aim with whatever you got left. Keep at it and it should be cake!

You should always have someone with you when you play to give you ideas on how to get through the level, gene splice, and make new weapons.