Although all the events in Legends of Mana can be done in any order, there are some that can be missed or failed EVEN if you place all the artifacts correctly. This Missable Events guide lists those events.
You can miss this if you never interact again with Bud.
This event can be missed if you ignore the 'Blessed Elixir' event.
Reentering Gato after completing 'Flame of Hope' makes Daena leave Domina and you can't start it.
Selecting the wrong options or talking to Peewee 10 times or more will result in him exploding and you will failing the event.
You will fail 'Dream Teller' and 'Diddle Had It' if you leave the map before completing them.
Completing 'Catchin' Lilipeas' quest before starting those 3 events will result in you losing access to them.
Both can be failed.
You can't get it unless you smash 20 crabs in the beach.
Entering Geo's cafe before completing events prior to 'Gilbert: School Amour' will automatically start that and not allow you to do the previous quests.If you pick the wrong options in 'Gilbert: Resume for Love', Gilbert will explode and you will fail the event. Resume for Love can also be missed if your start the event 'Cosmo' first.
Completing this event will end the game.
Take a look at our How to Unlock Artifacts guide to find out how to obtain the artifacts in Legend of Mana.