In Skylanders Ring of Heroes there are 10 types of rune and each has it's own unique set effect which is activated when you equip 2 or 4 runes of the same type. Listed below in no particular order are the runes along with their set effect.
Strike Rune
Increases ATK
Ward Rune
Increases DEF
Hit Rune
Increases Accuracy
Energy Rune
Increases HP
Rage Rune
Increases CRIT DMG
Hope Rune
Decreases Block DMG
Focus Rune
Increases Accuracy
Fatal Rune
Increases CRIT Rate
Resist Rune
Increases RES
Dodge Rune
Increases Evasion
When you use a rune it will provide depending what the rune is (see above) a stat boost to the character. To view the stats of a rune you simply have to tap on it. Below are the stats you will be shown
ATK (Attack Power)
DEF (Defense)
HP (Hit Points)
CRIT Rate (Chances of activating a critical hit)
CRIT DMG (Critical Hit damage)
Endurance (Attack resistance)
Accuracy (Chances of landing a hit)
Evasion (Dodging)
Block Rate (Chances of blocking an attack)
Block DMG (The amount of damage when the attack is blocked)
ACC (Chances of an effect to turn out)
RES (Chances of resisting an effect)