Pokerus
I am goin to tell you about this virous that i have encounted on pokemon fire red and also on my pokemon emerald.For starters this is not like a disease or anything that could fully infect your game and make it never work again,its just a simple infection.Firstly if one of your pokemon have this Pokerus infection dont try and trade it because your probly just wasting your precious time compleating your pokedex.If you try and trde a pokerus infected pokemon its not going to harm your game it will just cancell the trade no big deal.Secondly your probly wondering how you can avoid catching this virous.Well you cant avoid it it just happens.Its usually on a pokemon that is obtained by a gameshark usually a shiny pokemon.
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