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Mewtwo - Round 1
After defeating everyone of Gym Leader Castle (Gyms, Elite Four, Rival) and all of the Cups in the Stadium, you will get the chance to battle Mewtwo. Mewtwo will be at Level 100 and knows the moves Psychic, Rest, Thunderbolt, and Blizzard. Fortunately, you get to use Six Pokemon to battle only Mewtwo.