10 Avid InventorSuccessfully invent at least 100 items
10 Five Fully Upgraded WeaponsFully upgrade five weapons
10 Four Fully Upgraded WeaponsFully upgrade four weapons
10 Fully Researched BouncerFully research the Bouncer
10 Fully Researched Gun SplicerThe player has fully researched the Leadhead Splicer
10 Fully Researched Houdini SplicerFully research the Houdini Splicer
10 Fully Researched Little SisterFully research the Little Sister
10 Fully Researched Nitro SplicerFully research the Nitro Splicer
10 Fully Researched RosieFully research the Rosie
10 Fully Researched Spider SplicerThe player has fully researched the Spider Splicer
10 Fully Researched Thug SplicerThe player has fully researched the Thuggish Splicer
10 Hacked a SafeThe player has successfully hacked a safe
10 Hacked a Security BotThe player has successfully hacked a security bot
10 Hacked a Security CameraThe player has successfully hacked a security camera
10 Hacked a TurretThe player has successfully hacked a turret
10 Hacked a Vending MachineThe player has successfully hacked a vending machine
10 Lucky WinnerHit the jackpot at a slot machine
10 Three Fully Upgraded WeaponsThe player has fully upgraded three weapons
10 Toaster in the TubThe player has shocked an enemy in the water
100 Brass BallsComplete the game on Hard difficulty without using a Vita-Chamber.
20 Maxed One TrackThe player has purchased every slot in one of the Plasmid or Tonic tracks
20 Quality Research PhotoThe player has taken a Research Photo of the highest grade
20 Research PhDMax out all possible research
20 Weapon SpecialistAcquire all upgrades for all weapons
25 Ammo InventorThe player has successfully invented all possible ammo types
40 Dealt with every Little SisterThe player has either Harvested or Rescued every possible Little Sister
40 Seriously Good at ThisThe player has completed the game on the Hard difficulty setting
40 Skilled HackerThe player has successfully completed 50 hacks
5 Basic InventorThe player has successfully invented at least one item
5 Bought One SlotThe player has purchased one slot in any Plasmid or Tonic track
5 One Fully Upgraded WeaponThe player has fully upgraded one weapon
5 One Successful HackThe player has performed at least one successful hack
5 Prolific PhotographerTake at least one photo in every research group
5 Researched a SplicerThe player has taken at least one Research Photo of a Splicer
5 Two Fully Upgraded WeaponsThe player has fully upgraded two weapons
5 Upgraded a WeaponThe player has acquired at least one weapon upgrade
50 HistorianFind every audio diary
50 Maxed All TracksPurchased every slot in all four Plasmid and Tonic tracks
50 Tonic CollectorCollect or Invent 58 Tonics in the Physical, Engineering and Combat tracks