Save your ammo
There is a way that you don't have to waste so much ammo in the begining and eventually run out. By shooting the Los Ganados in the head or legs, and then running up and kicking them or knifing them, you save lots of ammo, plus you can do it to multiple enemies.
More tricks, tips and cheats for this game are right here - Resident Evil 4: Wii Edition cheats
Comments for this hint