Always Black suit Spidy
First off, if you have completed the game this wont work, but the good news is that Spider-man 3 on PS2 is real short (took me 2 hours). Before you fight Sandman for the first time the Black suit will be stuck to you, and you cannot be killed (almost), when you build up your black adren. You preform 1-hit-kills.
(WARNING DO NOT GO SEE MJ AS THIS WILL WEAR OFF)
Each time you switch off your console you lose your adren. And it's the same if you die or jump into water.
More tricks, tips and cheats for this game are right here - Spider-Man 3 cheats