Completing Final Dr. Connors Misison
Hold Slow Motion on the last Dr. Connors part 2 mission while placing the serum into the canister and then Web-Zip to the left onto the platform as soon as you come into play (don't jump, only Web-Zip). Stay there without moving and wait for time to run out. No more Lizards will appear while you wait.
More tricks, tips and cheats for this game are right here - Spider-Man 3 cheats
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