On the 'Turismo' mission for El Burro, do it ASAP [As soon as possible] while all/almost all gangs like you in Portland. If you do this mission after leaving Portland for Staunton Island and killing Salvatore, the checkpoints in St.Marks and it's area will be hard/near impossible to get through without having your car caught on fire by a shot gun blast or blown up on the spot by the mafia as you drive by. Getting out and getting another car can lead to the new car being shot up while your jacking it or you getting shot when out and about. Using the health cheat in the car can help, but personally I'm doing the game without cheats first and then using cheats after I beat the game and on future files.
In the 'Arms Shortage' mission, The mission for the man in the park where you protect his army buddy from the Colombians, go to Ammu-Nation and stock up on everything that isnt the Sniper Rifle as it is useless in this mission. Go and take any car to the mission and stock up on the weapons he gives you behind him. Wait directly where the gate would normally close and open and wait for the first Cartel truck to park, and throw a grenade DIRECTLY behind the truck, as to attempt to blow up that truck and the truck behind it and any Cartel near them. Run back to the crates and hide and kill the men that come up from behind the building because if you don't kill them they will kill you AND phil from behind as you are engage in a firefight with the Cartel from the trucks, after you kill the 'Building Cartel', just use the crates for protection and occasionally pop out and AK/M-16/UZI to kill the Cartel, and Grenade or cocktail anyone near the gates.
In the Asuka Part 2 mission 'Espresso-2-go' you can use one of two methods the 'Ram method' where you just ram the stands with a car, or the ' Blow it up method' where you get out and use a rocket launcher on them, if you use this method be sure your a few steps from your car as to not hit it and kill yourself instantly. Anyhow, start with the stand at the Shoreside vale hospital since the clock doesnt start until the first stand is gone, from there go out to the left and down the road to the airport go all the way down the front of it and up the stairs for number 2, go THROUGH THE TUNNEL to Staunton Island because the bridge can cost you 30+ seconds because of the part that goes up and down. Get the three near the torrington area, the one in the park and the one near the Newport carpark, from here you can use the Callahan Bridge since it is in one solid piece, ideally you want at least 2 minutes to complete Portland, from the bridge go straight to Portland Harbor and get that one, go towards Salvatore's mansion like a bat out of hell and hope the Mafia doesnt blow up your car before you get to the stand right on the corner. I recommend coming from the other side and speeding down the street as to have the speed to hit the stand, otherwise you may be to slow to kill it, and be blown up.
One more, for the Decoy mission for Don Love, get in the Securicar and sit in the truck for as long as possible until someone [S.W.A.T, Police, Army, whoever] gets near the warehouse and take off to the right up the ramp and over the wall, take this route and you should do this correctly. Warehouse>Draw Bridge[ Pray that the whole bridge is in one piece] >The Callahan Bridge>Portland>[Depending on the amount of time left just run around[15 Secs. Or less, or go some where Isolated like the sub way tunnel, 45+ Seconds left], this should work first time out depending on your luck, driving skill, and damage amount.
Good Luck, Hope I helped!!!
Added by: CK20 Jul 31st 2009, ID#32188