Assassin's Creed II Guide - Walkthrough
Assassin's Creed II picks up right where the first Assassin's Creed left off -- with test subject Desmond Miles trying to make sense of the strange messages and symbols he has discovered on the wall of his room in the Abstergo Industries research facility, where he is being held prisoner.
When Lucy Stillman appears, follow her over to the Animus table. After the cutscene, press any button to get on the Animus. Press the buttons shown on screen during the ensuing cutscene.
Once you have regained control over Desmond, follow Lucy out into the hall. Note that Desmond can now Sprint (hold RT on the Xbox 360 or R2 on the PS3). Continue following Lucy through the halls and to into an elevator. When the elevator stops, you must make it through to the other side of the large room while avoiding the patrolling guards. Just follow closely behind Lucy; if a guard spots you, keep running.
Escape Abstergo Industries!
When you reach the elevator keypad at the other end of the room, hold Y or Triangle to have Desmond figure out the passcode. A group of guards will confront you in the parking garage. Not one of the guards is armed, so they can be easily dealt with. Press LT/L2 to lock on to a guard and then use the X/Square button to punch. Hold RT/R2 to Deflect; press A/X while holding RT/R2 at the right time to dodge an enemy's swing.
After the fight, follow Lucy to the getaway vehicle to trigger a cutscene. When you regain control over Desmond, follow Lucy up to the hideout. Watch the cutscene and then chat with Lucy twice. Talk to Shaun Hastings and Rebecca Crane as well. Then, stand by the side of the Animus opposite of Rebecca and press any button to get started on the first memory sequence.