Take it Slow
Although there are a few areas where you have no option but to be quick you will find that for the most part a slower, deliberate approach works about 90% of the time.Pick Up Stem Cells and Credits
Make sure you pick up every single stem cell and credit you come across. Once you fully upgrade your character you will be stronger than the enemies.Locate the Med Bay
Use the map to locate the med bay and use that as your safe room. In The Persistence enemies cannot follow you into a med bay and you will find weapons and supplies there.Kiosk Upgrades
Pressing the right bumper on your controller when you are at the weapon/gadget kiosks will take you to an upgrade screen. You will be able to upgrade each item several times if you have the credits. Updates do not reset when you die.How to get Access Cards
The first supply crate that you open on each level will have an access card that allows you to directly access that level from the deck porter in the starting area.Upgrade Rage Serum
Upgrade the Rage Serum early, it makes you go berserk and can't die. Save them for areas where there there are many or stronger enemies. They come in handy around supply crates.Loot Everything
Make sure you loot everything you come across. There is plenty of money and stem cells to find and you will need all of it.
How to get Crafting Materials and Schematics
The Persistence tips
Challenge rooms can be a great way to get crafting materials and schematics. Make sure they have what you want before entering. The big rooms have you fight waves of enemies, while the long hallway is a race to the other side before you die. Crafting Weapons
Use deck 1 to craft all your weapons and items. It is the easiest one with the weakest enemies and you will often have all machines you need on the same deck. All you need to do is bounce around from machine to machine once you are ready to stock up.Don't Waste Ammo
Try to save your ammo, you will usually find that a swift stem cell bash to the face is often enough to take down basic enemies.Avoid Enemies with Guns
Keep an eye out for enemies that have guns as they have good aim and range and will take you down quickly if they get you in their sights. The best way to take down this type of enemy is to senak up on them and stem cell them in the neck or Valkyrie them silentl..