Earth has fallen siege to Ultimus and his sinister forces, this has forced heroes and villains alike to forget their differences and battle side-by-side against one of the biggest threats the world has ever seen. It's now up to you to take command of S.T.R.I.K.E. (Strategic Tactical Reserve for Interdimensional Key Events) and try to defeat the Kree warlord with a team of five Marvel characters you have put together.
The game begins with a brief tutorial that gives you the opportunity to learn the basics of the game and how the different aspects function. This amongst other things will include the training of characters, how to attack, using of skills, and orbs. Initially you will start the game in Campaign mode with Spider-Man, Shield Medic, and Luke Cage as your squad but you will be able to unlock additional characters by buying orbs, the Arena shop, the Raid shop, and completing story missions. As well as campaign mode Marvel Strike Force features plenty of different game modes such as Events, Milestones, Challenges, Arena, Alliance Raids, and Alliance War. These modes are unlocked by upgrading your level and completing Campaign mode’s levels.