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If you make a mistake and drop a block before changing it to the colour configuration that you want you can tap the screen as it is falling to switch it around again.
You can eliminate 3 blocks in one go if they are ALL in a row either horizontally or vertically, this will also eliminate any block of the same colour that is also connected to the matching row.
Make sure you collect the power ups whenever they appear on screen because you are not given another opportunity to pick them up. The only colour power-up you have to avoid tapping are the red ones as these are booby traps.
To eliminate white X blocks completely just make a bomb combo near them. When you encounter falling white X blocks in the later levels there is nothing that you can do with them but to work around them.
Before using up the fourth block in the current batch you should first try to stack as many of the same coloured blocks together as possible.