Jackman10k

Best answer as chosen by Asker / Ratings
I personally find it much better on the Wii than on the Gamecube or PS2, but that's just me. To find the one for you, we would have to break each one down to answer your other questions, like so:

Gamecube: The first edition of RE4, also has the easiest to grasp controls (Compared to the PS2) and would be good for beginners, but doesn't have the bonus content that the Wii and PS2 carry.

PS2: Considered inferior to the Gamecube version at it's release due to lower resolution and graphics, but carried additional content.

Wii: Also has the bonus content the PS2 contains, but is declared much more fun to play with the motion controls creating a feel of "You're in the game." As far as how well the motion sensors work, I have this version and they work splendidly, moving as you move, no less and no more. The only fault one would find with this game is that person could not aim with the wii control well, which gets better with time. The controls are also simple to grasp. Though not as easy as the Gamecube version.

So it can be said like this:

Gamecube: If you don't think you can play the other ones well due to control limitations or awkwardness, get this one.

PS2: If you can't aim on the Wii edition to save your life and want the additional content, get this one.

Wii: If you have no problems with the aiming or controls on this version, it's the one you should get hands down.

Killer9898

Best answer as chosen by Asker / Ratings
So much better because of the motion and the reticule in the middle is all ways in the same position so unlike the play station 2 aiming (the little red light) it's easier to target people far away.