The Binding of Isaac: Afterbirth + Cheats and Tips

Complete the following tasks to unlock the corresponding mode, character, boss, or alternate floor.

Afterbirth + Bosses and Champion Variants:

Defeat The Lamb.

Apollyon:

Defeat Mega Satan.

Burning Basement:

Defeat Mom's Heart 11 times.

Greedier Mode:

Donate 500 coins to the Greed Machine.

When you collect the following items you will gain the corresponding effect.

Aquarius:

Leave trail of tears that damage enemies.

Aries:

Movement speed increases, and grows horns on head that can damage enemies.

Cancer:

Get 3 spirit hearts, the ability to inflict poison on contact, and convert damage over time into half hearts.

Capricorn:

ALL stats increased, get one bomb, and key and coin.

Gemini:

Gemini's baby appears on Isaac and damages nearby enemies.

Leo:

Break rocks by walking on them.

Libra:

Get 6 keys, bombs and coins, and have ALL stats balanced.

Pisces:

Tear upgrade and their knockback is increased.

Sagittarius:

Tears are piercing and have faster rate.

Scorpio:

Tears are poisonous, and tear stats lowered.

Taurus:

Movement speed decrease but gets faster when enemies are present. When fast enough, can damage enemies on contact.

Virgo:

Empty red heart containers refilled, and get temporary shield once per room.

Complete the following tasks to unlock the corresponding Challenge. When you then complete the Challenge you will unlock rewards that will generate in subsequent games (Challenges 1-3 and 12-18 are available at the beginning).

Challenge 4 - Darkness Falls:

Defeat Mom's Heart a total of 11 times

Challenge 5 - The Tank:

Possess a total of 7 Red Heart Containers at any point during a run (unlocks Magdalene)

Challenge 6 - Solar System:

Defeat Mom's Heart a total of 3 times

Challenge 7 - Suicide King:

Defeat Mom's Heart a total of 11 times

Challenge 8 - Cat Got Your Tongue:

Collect 3 Guppy Items during a single run (Become Guppy)

Challenge 9 - Demo Man:

Defeat Mom's Heart a total of 9 times

Challenge 10 - Cursed!:

Possess a total of 7 Red Heart Containers at any point during a run (unlocks Magdalene)

Challenge 11 - Glass Cannon:

Defeat Loki once and clear The Family Man challenge

Challenge 19 - The Family Man:

Collect both Key pieces from the Angels in a single run

Challenge 20 - Purist:

Defeat Mom for the first time

Challenge 21 - XXXXXXXXL:

Defeat Mom for the first time

Challenge 22 - SPEED!:

Defeat Mom for the first time

Challenge 23 - Blue Bomber:

Defeat Mom's Heart a total of 11 times AND destroy at least 10 tinted rocks

Challenge 24 - PAY TO PLAY:

Defeat Issac as Cain

Challenge 25 - Have a Heart:

Defeat Mom for the first time

Challenge 26 - I RULE!:

Defeat either The Lamb or ??? At least once

Challenge 27 - BRAINS!:

Defeat Issac a total of 5 times

Challenge 28 - PRIDE DAY!:

Defeat Mom for the first time

Challenge 29 - Onan's Streak:

Defeat Satan while playing as Judas

Challenge 30 - The Guardian:

Defeat Mom for the first time

Challenge 31 - Backasswards:

Defeat either The Lamb or ??? At least once

Challenge 32 - April Fools!:

Defeat Mom for the first time

Challenge 33 - Pokey Mans:

Defeat Mom's Heart a total of 11 times

Challenge 34 - Ultra Hard:

Defeat either The Lamb or ??? At least once

Challenge 35 - Pong:

Defeat Issac a total of 5 times

When you complete the tasks below you will unlock the corresponding playable character. Each character starts with different stats, items, and abilities.

Azazel:

Exchange hearts for Devil power-ups at least 3 times in a run.

Cain:

Possess at least 55 pennies at any point during a run.

Eve:

Complete two consecutive floors without picking up any hearts (of any kind).

Lazarus:

Possess a combination of at least 4 Soul/Black Hearts at any point during a run.

Lilith:

In Greed mode, defeat Ultra Greed while playing as Azazel.

Magdalene:

Possess 7 or more Red Heart Containers at any point during a run.

Samson:

Complete two consecutive floors without taking any damage.