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Have one of your characters equip the Gas Launcher with at least one gas round and then engage the enemy in battle. When you use the 'run' feature and press 'Start' to try to escape. Regardless of whether or not the pointer hits the center you will wipe out ALL the zombies in the area without depleting your ammo count.
Complete guide to Resident Evil 5, includes 30+ videos with detailed gameplay and strategies to be..