The Easiest Way To Kill ANYTHING (Esther required)
If you don't have Esther, it's a gun at gun runners but you need Gun Runner's Arsenal. You will also need one mini nuke big kid. Use the "Hotkey Ammo Glitch" to hotkey the mini nuke big kid heres the link for the explanation http://www.youtube.com/watch?v=jW9lHXS91tc. (go to your pip boy, select Esther, hold down RB, scroll to ammo with the analog stick, scroll to Mini nuke big kid, press a hotkey button). Get a melee weapon and equip (I personally use the shishkebob), and then press the hotkey button that you hotkeyed the mini nuke big kid with. Now that thing is a one or two-hit kill every time.
Added by: mrjohns Apr 9th 2014, ID#9672