When the other team is using the big hit power up there are two ways to strike him out.

Number 1 : If you have a power up that you didn't use, use it. If you keep hitting a perfect pitch, he will strike out. If he strikes out, you will get an extra 100000 points (another power up).

Number 2 : If you don't have a power up, there is another way you can strike him out (only works if you have a pitcher with a 4-5 star fastball pitch). Keep doing perfect fastball pitches and pitch at the bottom corner where they are standing. You will get a good chance to strike him but 1 wrong move will make the other team hit a homer.

I hope you enjoy!

For a easy homer this is what you do:

Hold up on the numchucks, hold A, and wait for a power player. I suggest Albert Pujols.