Head to the area and have your Profiler open so you can find Angelo Tucci’s niece. Once you find her, get in the right distance to hack her phone remotely. Hack her phone the second time to eavesdrop her calling your target.
Once Angelo Tucci’s location and projected path is revealed, find a vehicle and intercept him. The best way to deal with him is to wait for him ahead and ambush him. You can use a sniper rifle or do the old way of blowing his car up using your grenade launcher. Take note that if Angelo manages to slip past you, he’ll call for reinformcents, making your job harder. After killing him, the mission will be complete.