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The Last of Us Walkthrough and Guide
Depending on the difficulty, you'll find more or less items during your quest for survival. The harder the difficulty, the less items you'll find. You'll still be able to find all collectibles regardless the difficulty you're playing on.
Note: Not all items disappear on harder difficulties. Weapons, Skill Pills, Parts, Training Manuals, Comics and Artefacts can be gotten during any of your playthroughs.
The harder the difficulty, the more damage you take from enemy blows. Some enemy attacks (such as a Clicker grapple) retain their instant-kill effect on all difficulties. Enemies will also notice you considerably more quickly the harder the difficulty.
The Easy difficulty also has an additional option for 'Lock On Aiming', which makes it easier to shoot targets.
The Survivor difficulty doesn't have a Listen Mode nor Melee Prompts for in-game combat. You'll want to be very familiar with the game before attempting it.