This is a dedicated section that is part of the main quests Kill Yuriko and Kill the Black Samurai. After the main Quest “An Important Rendezvous” and choosing to meet up with Jonathan in Naraku, you’ll have to head back to Tsukiji Honwanji to slay Lilith.
Travel to Ginza via terminal then exit south through the Honwanji passage. Head to the temple only to find one of Tayama’s men telling you about a secret passage behind the bench. Select it as one of the options in your lower screen and you’ll be inside the hidden passage.
Follow the path and open the door to reach the Shelter Ruins. Make your way to the south and save your game before entering the southernmost room. Here, you’ll fight a boss.
LV44 Girimekhala
Repel: Phys
Drain: Gun
Null: Light, Dark
It can use Mabufudyne and increase its physical attacks using Tarukaja. Since it doesn’t have any elemental weakness, it will help having Demons with high Ma stats and preferably defenses against ice and physical attacks. Using Tetrakarn is also beneficial in this battle since it is fond of using Megaton Press and Berserker God. This boss has also three press turn icons so reflecting/blocking or draining his attacks is a good way of getting rid of his turns.
You’ll still be inside the demon’s domain. Make your way south and make sure to save before approaching the door. Approach the door to fight another boss demon.
LV47 Dakini
Weak: Ice
Drain: Fire
Null: Light, Dark
Exploit this boss’ weakness using ice attacks. You only need to watch out for its Mudoon that has a high success rate of instantly killing you and your Demons one at a time. Having a demon that can nullify this attack will be a good way of ensuring victory. As usual, use buffs, debuffs and heal your party whenever necessary. It’s HP is just around 1500 so it shouldn’t take you that long to take her out.
Save your game and heal up. Equip the best gun and non-elemental ammo you have. Carry Demons that can heal your party and make sure their MP is full. Also, you have to make sure that none of the demons you’ll bring are weak against elec and gun attacks.
When ready, enter the door to face Lilith.
LV50 Lilith
Weak: Gun
Resist: Fire, Ice, Force
Drain: Elect
Null: Light, Dark
At this point of the game, you should already have good gear and weapons. Lilith can use Megidola which can bypass any defense you have, Spirit Drain to remove all buffs and debuffs, Dream Needle that can deal weak gun damage but has a chance to inflict Sleep and Maziodyne. Since Lilith has defenses against elemental attacks, you’ll need Demons that can use gun or almighty attacks. Lilith also has three press turn icons so it will help being able to reflect, nullify or absorb her attacks.
After dealing around enough damage to Lilith, she’ll talk to you. Depending on your responses, Lilith’s stats will be affected. Choose to smile at Lilith to decrease her defense. Continue attacking and she’ll ask you another question. Select “I feel it not at all” to further decrease her defense. This can be a long battle since her HP is around 6500.
Continue your attacks and heal up if necessary. After defeating Lilith, the quests Kill the Black Samurai and Kill Yuriko. Another main quest will open: I Sense an Uneasiness.