If you are playing a character (SHEVA) in 6-3
If you are playing SHEVA and running with Christ... You won't worry about keeping Hold button or you won't go to broken bridge (when she falls down)... Let Wesker jump to another land and see his LONG arm as his weapon)... When He will tell you shoot him from back and choose Rocket Launcher and then shoot on the floor (when he was walking and smashing blindly to your partner) then game ends...
Good luck
More tricks, tips and cheats for this game are right here - Resident Evil 5 cheats
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