KrnACxHunta

This one's tough to answer, but it's good if you have at least two people in the room with you, and if both of you know cold spells of any kind, that's good too.

Best is two sorceress, both ice spells, both with the teleport ability.

First off, when both of you walk in, make sure you both make tps on the opposite sides of the room, and whenever you're about to die and you want to run.

Make sure you take your ally's tp and not your own so that you can go back as many times as you want without your tp going away.

First off, Duriel is REALLY fast, and since the room is really TINY, it's kinda hard. BUT he's melee.

YAY. so just slow him with frozen orb a few times and when he gets too close, just teleport to the other side of the room and blast him with frozen orb there.

(Act 3 mercenary (ice) wil help a lot here because he'll help you with his ice spells)

Blade127

Another strategy (only if you need quest, otherwise why the hell are you goin against Duriel?) is to open the chamber, get a high level, kill Duriel --Don't be fooled by "You cannot complete this quest in this game"--, go and talk to Tyrael with the character that wants the quest, talk to jerhyn and meshif, and you have the quest, and now able to go to Act3.

--Mainly works only on the Battle.net realms, can be attempted if another person is in game on Open Battle.net--