Unlock Hand Cannon
When you have completed the game under the Hardcore difficulty setting this weapon can be found at the first shop in a New Game+. The hand cannon has unlimited ammunition and one hit kill capability, it resembles a foam finger and when fired Isaac makes 'Bang Bang' and 'Pew Pew Pew' noises.
http://www.youtube.com/watch?v=eBS86rAT4W0
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