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Multiplying cells only flip those that are next to them so try and grow into spaces that don't lead to you being adjacennt to the enemy. That way when the enemy grows into a space next to you you will be able to unleash a transforming wave onto them that will take away their opportunity to respond.
Athough tempting try not to use use your most powerful cells as soon as they beccome available,it is more beneficial to save them and maximise their usage.
Although stacking C-cells to build permanent walls is helpful the chain reaction that can be caused by a well-placed stack on top of a lowlier cell type can completely change the game state in your favour as it will flip a lot of enemy cells to your colour.