You can complete your quests and activities at this point since you won't be able to turn back once the mission starts. You can still continue however, as soon as you complete your journey. Fast-travel to the compound and talk to Sam when ready. Once inside play a game of poker until things escalate quickly.
Bet your life twice then you'll have to fight Hoyt using your knife. You have to press the correct buttons during the QTEs (Quick Time Event) to kill him and complete the mission.
I don't need 10 fingers to use a knife