Mission Two Safe
Combination is 451. You can find it on the wall right near the safe, behind some whiskey bottles.
Mission Two Safes
Combination is 203, and can be found in the Bunks in the back yard AREA of the mission. Once you enter the backyard, Save a good overseer and his female friend from an evil overseer with a mask. He will then give you the combination.
The Kennel Safe
The kennel safe is a riddle. You will need the Loot Cache note, and the Seven Strictures to figure it out, unless you just put in 217 right now.
If you want to solve it, first pick up the lever in cell E, place the lever on F. then open up Cell F. Pick up the seven stricture book. This will give you the seven strictures in order.
The Loot cache note which can be found, near the back or start of the kennel pending on which way you came in, is easier to find. But it tells you the 3 strictures. Then all you do is match them to the appropriate numbers.
217 is the combination.
: Dr Galvani's Safe :
The Code is 287. How To get the code, you will need Galvanis personal journal which is located in his room. The Safe itself, is also located on the same floor.
He mentions something in the journal about his favorite day being the 28th of the 7th month. Something similar perhaps. either way the code works and it's in the journal if your wondering.
Combo is 287.
Mission Three Safe
One safe in the Art Dealers apartment. Problem is It is difficult to get to.
First you must find out who the art dealer is if you would like, by completing and meeting Slackjaw at the Dunwall Distellry.
You will also be able to get a key from a woman in the Distellry streets, IF you help her escape from the guards.
If you manage to get into the Apartment, the combination also CHANGES randomly with each game load. So you MUST find it out yourself.
The annoying part is you must travel to the art dealer via marker, to The Golden Cat, look for the interrogation room if you don't have the marker.
Once you find him Electric shock him with the lever about 5 times until he talks. The 5th shock should net an option to ask him for the safe combination.
Then with the combination which will be in your notes now. Go backtrack to the art dealers apartment. Put in the Combination for a ton of stuff !
Mission Four Safe
This one is in the second part of the mission. Inside Prachetts house. You can Blink or climb inside, then get the key off one of the guards inside.
The combination is always 473. But to get it, you must look at all the paintings. THREE of them, have numbers on it. Then input the combination in order scene.
There will be a RUNE inside. Among some gold ignots.
Mission Six Safe
In Lord Regents Chambers
Mission Seven Safe
Underwater near the wooden beams and some river krust enemies.