5 Bought a SlotBuy one Plasmid or Tonic Slot at a Gatherer's Garden.
5 First ResearchResearch a Splicer with the Research Camera.
10 Disgusting FrankensteinBecome a Big Daddy for the first time in a non-private match.
10 Fully Upgraded a PlasmidFully upgrade one of your Plasmids to the level 3 version at a Gatherer's Garden.
10 Fully Upgraded a WeaponInstall the third and final upgrade to any of your weapons.
10 Man About TownPlay at least one non-private match on each multiplayer map.
10 Max Plasmid SlotsFully upgrade to the maximum number of Plasmid Slots.
10 ParasiteAchieve Rank 10.
10 Two-Bit HeroicsComplete your first trial in a non-private match.
10 Unnatural SelectionScore your first kill in a non-private match.
10 Upgraded a WeaponUpgrade any weapon at a Power to the People Station.
10 Welcome to RaptureComplete your first non-private match.
15 Big SpenderSpend 2000 dollars at Vending Machines.
15 Master ProtectorGet through a Gather with no damage and no one getting to the Little Sister.
15 Trap MasterKill 30 enemies using only Traps.
20 'Mr. Bubbles-- No!'Take down your first Big Daddy in a non-private match.
20 All PlasmidsFind or purchase all 11 basic Plasmid types.
20 All Weapon UpgradesFind all 14 Power to the People weapon upgrades in the game.
20 Little MothAchieve Rank 20.
20 Master HackerHack 30 machines at a distance with the Hack Tool.
20 Mother GooseSave your first Little Sister in a non-private match.
20 One Research TrackMax out one Research Track.
20 Prolific HackerSuccessfully hack at least one of every type of machine.
20 Proving GroundsWin your first non-private match.
20 Research MasterMax out research on all 9 research subjects.
20 Skin JobAchieve Rank 30.
25 Big Brass BallsFinish the game without using Vita-Chambers.
25 Grand DaddyDefeat 3 Big Daddies without dying during the fight.
30 Against All OddsFinish the game on the hardest difficulty level.
30 Master GathererGather 600 ADAM with Little Sisters.
40 Rapture HistorianFind 100 audio diaries.
50 Choose the ImpossibleAchieve Rank 40.
50 Dealt with Every Little SisterEither Harvest or Save every Little Sister in the game.